THE RELEVANCE AND IMPORTANCE OF TUMOR INFILTRATING LYMPHOCYTES (TILS) IN BREAST CANCER

Tumor infiltrating lymphocytes (TILs) were evaluated in many cancers like ovarian tumors, endometrial colon cancer and melanoma. Now there is increasing trend evaluating TILs breast cancer. gives the patients immune response to tumor. 100 cases of Modified radical mastectomy specimen chosen from surgical pathology records. The representative formalin fixed paraffin embedded tissue samples collected. Detailed history regarding Patients age, sex, side involved , Grade neoadjuvant chemotherapy assessed for cases. Infiltrating Lymphocytes are with Immuno HistoChemistry CD45 CD3 which 93% Ductal carcinoma-NOS 07 % special types Mucinous, Metaplastic, Apocrine, Medullary carcinoma. Results: In our study, Highest incidence carcinoma occur age group 41-50 years. Carcinoma NOS most common primary malignant neoplasm constituting Most tumors left sided. Forty seven percent presented size range 2-5cms. Majority II accounting 63.5% all three variables 0- 10 20- 40 50- 90 %.Younger more TILs. Neo adjuvant had significant correlation (P= 0.05).